Associations of single nucleotide polymorphisms in the adiponectin
gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer
Affiliations: Department of Pathology, Kuwait University, Safat,
Kuwait | Department of Medicine, Faculty of Medicine,
Kuwait University, Safat, Kuwait
Note: [] Corresponding author: Dr. O.A. Mojiminiyi, Department of
Pathology, Faculty of Medicine Kuwait University, PO Box 24923 Safat, Kuwait,
Code 13110. Tel.: +965 25319476; E-mail: [email protected]
Abstract: Objectives: The aims of this study are to (1) study the influence of
polymorphisms in adiponectin gene on adiponectin levels and potential
associations with breast, prostate and colon cancer; (2) investigate the
associations of adiponectin levels with other adipokines and breast, prostate
and colon cancers. Subjects: We measured fasting adiponectin, leptin,
insulin, Sex steroids in 132 (66 females, 66 males) cancer patients and 68 age
and sex matched apparently healthy subjects. Body Mass Index (BMI) and waist
circumference were used as indices of obesity. Insulin Resistance was assessed
using Homeostasis Model Assessment (HOMA). Three single nucleotide
polymorphisms (SNP rs182052 (G-10066-A), SNP rs1501299 (276G > T), SNP
rs224176 (45T > G) in adiponectin gene were studied using Real Time
Polymerase Chain Reaction. Results: GG genotype of SNP rs1501299 was
significantly associated with higher levels of adiponectin (OR=1.2,
95%CI(1.03–1.3), p = 0.02); breast (OR=8.6, 95%CI(1.03–71), p =
0.04), colon cancers (OR= 12, 95%CI(1.2–115), p =0.03). GT genotype
was also associated significantly with colon cancer (OR=2.6, 95%CI
(1.1–6), p =0.03). However SNP rs224176 was associated with only breast
cancer. Conclusion: Our results demonstrate that adiponectin gene SNP
rs1501299 and SNP rs224176 may be the predisposing factors in some cancers but
our results differ from what has been reported in other populations suggesting
a complex relationship between genetic variations and phenotypic adiponectin
levels.
