Affiliations: Endocrinology and metabolism research centre, Tehran
university of medical sciences, Tehran, Iran | Otolaryngology and head & neck surgery research
centre, Tehran university of medical sciences, Tehran, Iran | Department of Pathology, Shariati hospital, Tehran
university of medical sciences, Tehran, Iran | Immunogenetics Lab, Department of Immunology, Tehran
university of medical sciences, Tehran, Iran | Hematology-Oncology and Stem Cell Research Center,
Tehran university of medical sciences, Tehran, Iran
Note: [] Corresponding author: Mahsa M. Amoli MD, PhD, EMRC, Dr Shariati
Hospital, North Karegar St., Tehran 14114, Iran. Tel.: +98 21 88220037 8; Fax:
+98 21 88220052; E-mail: [email protected]
Abstract: Objective: Papillary thyroid carcinoma (PTC) is the most frequent
types of thyroid malignancies. Several genes may be involved in susceptibility
of thyroid cancer including Human Leukocyte Antigens (HLA). The association of
thyroid carcinoma with HLA alleles has been previously studied in other
populations and certain HLA alleles were shown to be either predisposing or
protective. The aim of this study was to determine the association between
HLA-DR and papillary thyroid carcinoma in an Iranian population. Design: HLA-DR antigen frequencies were determined in patients with papillary
thyroid carcinoma (N=70) and non-related healthy controls (N=180) using
PCR -SSP. Main Outcome: We found that HLA-DRB1*04 frequency was
significantly higher in our patients compared to the controls [P=0.02, OR;
1.9, 95% CI (1.04–3.57)]. Conclusions: Our results revealed
HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian
population. This confirms the previous findings for associations between
HLA-DRB1 and differentiated carcinomas in other populations.
