CYP1A1 genetic polymorphisms in Ecuador, South America

Article type: Research Article

Authors: Paz-y-Miño, César^; | Arévalo, Melissa | Muñoz G., María José | Leone, Paola. E.^;

Affiliations: Laboratorio de Genética Molecular y Citogenética Humana, Escuela de Biologiá, Quito, Ecuador | Facultad of Medicina, Pontificia Universidad Católica del Ecuador, Ecuador

Note: [] Corresponding author: César Paz-y-Miño, MD., Laboratorio de Genética Molecular, y Citogenética Humana, Pontificia Universidad Católica del Ecuador, Apartado 17-1-2184, Quito, Ecuador. Tel./Fax.: +593 2 2991688; E-mail: [email protected]

Abstract: A total of 108 individuals from the Ecuadorian population from rural and urban places were analyzed for two CYP1A1 gene polymorphisms. The frequency of the val allele at codon 462 was 0.50, while the frequency of the Msp I restriction site, m2 allele at the T6235C position was 0.70. These polymorphisms in Ecuador have higher frequencies if we compare with others around the world, with the exception of some South American population in Brazil and Chile.

Keywords: phase I enzymes, CYP 1A1, PCR-RFLP

Journal: Disease Markers, vol. 21, no. 2, pp. 57-59, 2005