Affiliations: Istanbul University, Istanbul Medical Faculty,
Department of Medical Biology Istanbul, Turkey | Istanbul University, Istanbul Medical School,
Department of Internal Medicine, Division of Rheumatology, Istanbul,
Turkey | Trakya University Medical Faculty, Department of
Medical Biology. Edirne, Turkey
Note: [] Corresponding author: Dr. Fatma Savran Oguz, Istanbul
University, Istanbul Faculty of Medicine, Department of Medical Biology and
Bone Marrow Bank, Capa 34390-Istanbul, Turkey. E-mail: [email protected]
Abstract: The frequency and the distribution of HLA-B27 subtypes in
spondylarthropathy (SpA) patients and controls were investigated in a sample
Turkish population. B27 subtyping was performed by PCR-SSP method in two
groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of
SpA according to the European Spondyloarthropathy Study Group Criteria, and 55
HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the
Turkish population, and B*2705 was the predominant allele among patients with
SpA. The difference was mainly between male patients and male controls The
proportion of B*2705 among B27-positive patients and controls was significantly
different (P = 0.02). Our study supports other reports from
different populations which showed that B*2705 and B*2702 were more frequent in
Caucasian patients with SpA.
