Affiliations: Department of Biochemistry, Faculty of Science, Ain
Shams University. Cairo, Egypt | Department of Clinical Pathology, Military Medical
Academy, Cairo, Egypt | Department of Biochemistry, National Institute of
Diabetes and Endocrinology, Cairo, Egypt
Note: [] Corresponding author: Dr. M. Hesham Mahfouz, Faculty of Medicine
& Medical Sciences, Biochemistry Department, Umm Al-Qura University, P.O.
Box 7607, Makkah, Saudi Arabia. E-mail: [email protected]
Abstract: Diabetes mellitus is associated with disturbances in haemostasis
that could contribute to the development of thrombotic complications.The
present study was undertaken to determine the behavior of coagulation variables
and fibrinolytic system in diabetes mellitus. Forty five diabetic patients and
forty five matched controls were evaluated by doing the following haemostatic
parameter, prothrombin time, partial thromboplastin time, thrombin time,
coagulation factors assay II, VII, IX, & plasma fibrinogen, ADP-induced
platelet aggregation, protein C,a_2- antiplasmin, PAI and
FDPs. Generally diabetic patients have high levels of fibrinogen,
a_2- antiplasmin, & PAI and lower level of protein C.
Other haemostatic parameters did not show statistically significant difference
between diabetic patients and control group. Significantally elevated levels of
PAI, a_2- antiplasmin together with low protein C level in
diabetic patients may result in the disturbance of haemostatic balance favoring
thrombotic events. Conclusion: High levels of plasma fibrinogen,
a_2A- antiplasmin with low plasma protein C activity could
lead to a prothrombotic tendency in insulin dependent diabetic patients.
Moreover, in non-insulin dependent diabetic patients, the above mentioned
parameters together with high levels of ADP-induced platelet aggregation and
plasminogen activator inhibitor may increase the risk of thrombotic
complications. Obesity can be considered as an additional risk factor for
development of thrombosis in diabetic patients.
Keywords: diabetes mellitus, haemostatic disturbances, coagulation factors, fibrinolytic system
Journal: Disease Markers, vol. 19, no. 6, pp. 251-258, 2003,2004
