Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis

Article type: Research Article

Authors: Yen, Jeng-Hsien^; | Tsai, Wen-Chun | Lin, Chia-Hui | Ou, Tsan-Teng | Hu, Chaur-Jong | Liu, Hong-Wen

Affiliations: Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan | Department of Medicine, Kaohsiung Municipal United Hospital, Taiwan | Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan | Molecular Medicine Laboratory, Taipei Municipal Jen-Ai Hospital, Taiwan

Note: [] Corresponding author: Dr. Jeng-Hsien Yen, No. 100 Tzyou 1st Road, Kaohsiung 807, Taiwan. Fax: +886 7 3118141; E-mail: [email protected]

Abstract: The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms in the susceptibility to psoriatic arthritis. MnSOD gene polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphisms method in fifty-two patients with psoriatic arthritis and 90 healthy controls. The genotype frequency of MnSOD 1183C/T was significantly higher in patients with psoriatic arthritis than in controls. In contrast, the frequency of MnSOD 1183T/T was significantly decreased in patients with psoriatic arthritis. The phenotype frequency of MnSOD 1183C was significantly increased in patients with psoriatics arthritis in comparison to healthy controls. Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis.

Journal: Disease Markers, vol. 19, no. 6, pp. 263-265, 2003,2004