Affiliations: [a] Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA | [b] Jilin University, Changchun, Jilin, China | [c] Department of Pathology, George Washington University Medical Center, Washington DC, USA | [d] Department of Biophysics and Statistics, George Washington University Medical Center, Washington DC, USA | [e] Department of Surgery, George Washington University Medical Center, Washington DC, USA | [f] Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington DC, USA
Correspondence:
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Corresponding author: Yan-Gao Man, MD., PhD, Department of Gynecology and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, 20306, USA. Tel.: +1 202 782 1612; Fax: +1 202 782 3939; E-mail: [email protected].
Note: [1]
The opinions and assertions contained herein represent the personal views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense.
Abstract: Our previous studies revealed that beta protein 1 (BP1) was barely detectable in normal human breasts, but was seen in 21%, 46%, and 81% of hyperplastic, in situ, and invasive breast lesions, respectively. Our current study attempted to assess BP1 expression in inflammatory breast cancer (IBC), a very aggressive subtype of breast cancers characterized by extensive lympho-vascular invasion and involvement of dermal lymphatics. Paraffin-embedded tissue sections from 45 cases of IBC (nine with paired metastatic lymph nodes) and different controls were assayed immunohistochemically for BP1 expression. Positive BP1 immunoreactivities were present in all IBC cases. Strikingly, all cancer cells metastasized to lymph nodes and cells within lymphatic channels were uniformly and strongly immunoreactive to BP1. The percentage of BP1 positive cells and the intensity of BP1 immunostaining in IBC cases were significantly greater than those in non-IBC cases. Our findings suggest that BP1 may possess properties of onco-proteins that promote tumor progression, invasion, and metastasis, representing a putative signature marker for IBC and tumor aggressiveness.
Keywords: BP1, homeobox gene, inflammatory breast cancer, tumor invasion, metastasis
