Affiliations: Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Correspondence:
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Corresponding author: Liping Cao, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, Zhejiang, China. Tel./Fax: +86 0571 86090073; E-mail:[email protected]
Abstract: BACKGROUND: The miR-212 was among the top differentially expressed miRNAs in pancreatic
ductal adenocarcinoma (PDAC). OBJECTIVE: The aim of this study was to investigate the expression of miR-212 in PDAC
and evaluate its correlation with major clinicopathologic features and
patients' survival. METHODS: Fluorescence in situ hybridization (FISH) was adopted to examine miRNA
expression in 45 pancreatic cancer and 20 normal pancreatic tissues. The
relationship of miR-212 expression with clinicopathologic parameters and
clinical outcome was evaluated. RESULTS: miR-212 was confirmed to have significantly higher expression in PDAC
compared with normal pancreatic tissues (51.1% vs 10%, p< 0.01). High
expression of miR-212 was significantly associated with tumor size (p =
0.048) and tumor stage (p = 0.023). Moreover, in univariant analysis,
patients with high expression of miR-212 demonstrate significantly poorer
overall survival (p= 0.02). CONCLUSIONS: High expression of miR-212 in PDAC is associated with shorter overall
survival. It may be not only a potential prognostic marker, but also a
possible therapeutic target in PDAC.
