MALAT1 might be a predictive marker of poor prognosis in patients who underwent radical resection of middle thoracic esophageal squamous cell carcinoma
Affiliations: [a] Department of Digestive Disease, the First Affiliated Hospital
of Zhengzhou University, Zhengzhou, Henan, China | [b] Department of General Surgery, The Affiliated Cancer Hospital
of Zhengzhou University, Zhengzhou, Henan, China | [c] Department of Oncology and Institute of Clinical Medicine,
the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China | [d] Translational Medical Center, Zhengzhou Center Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China
Correspondence:
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Corresponding author:
Jiansheng Li, Department of Digestive Disease, the First Affiliated Hospital of Zhengzhou University,
Zhengzhou, Henan, China. Tel.: +86 13526403701; Fax: +86 021 64085875;
E-mail: [email protected]
Abstract:
BACKGROUND: Recent studies have demonstrated that MALAT1 is
involved in cancer metastasis and recurrence and it is up-regulated in
cervical cancer, hepatocellular carcinoma, non-small cell lung cancer
(NSCLC) and colorectal cancer. However, the role of MALAT1 in esophageal
squamous cell carcinoma (ESCC) is still unclear. METHODS: The expression of MALAT1 was evaluated in cancer
tissue and paired adjacent normal tissue samples from 77 middle thoracic
ESCC patients who received radical surgical resection using QRT-PCR. The
correlations between the expression levels of MALAT1 and
clinical-pathological features and Patients' survival were also analysed. RESULTS: MALAT1 expression was increased in ESCC tissue than in
adjacent normal tissue samples (P< 0.001). MALAT1 level was positively
related to pT stage (P= 0.01). Kaplan-Meier analysis showed high expression
levels of MALAT1 ware correlated with poor prognosis in ESCC patients.
Patients with a high level of MALAT1 had a shorter DFS and OS than those
with low MALAT1 expression (P= 0.04 and 0.038, respectively). On Multivariate
analysis, The HR of MALAT1 expression was 1.76 (95% CI = 0.97-3.21, P= 0.06) for DFS and 1.81 (95% CI = 0.97-3.41, P$=0.06) for OS. CONCLUSIONS: Our results showed that MALAT1 expression may serve as
a predictive marker for middle thoracic ESCC patients who have been received
radical resection.
Keywords: Esophageal squamous cell carcinoma, long non-coding RNA, MALAT1
