Affiliations: [a] Department of Endocrinology, Tianjin First Central Hospital, Tianjin, China | [b] Department of Endocrinology, First Affiliated Hospital, Inner Mongolia University of Science and Technology, Inner Mongolia, China
Correspondence:
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Corresponding author: Feng Wei, Department of Endocrinology, First Affiliated Hospital, Inner Mongolia University of Science and Technology, Inner Mongolia, China. E-mail:[email protected]
Abstract:
OBJECTIVE: To investigate the relationship between the expression
of transforming growth factor β 1 (TGF-β 1) and thyroid
lesions by retrospective analysis in patients with thyroidectomy. METHODS: Immunohistochemical analyses of TGF-β 1 were
performed with 120 archived formalin-fixed and paraffin-embedded thyroid
resection tissue samples that included 60 cases of thyroid cancers
(papillary thyroid carcinoma, follicular thyroid carcinoma), 14 cases of
nodular goiter (NG), 16 cases of thyroid adenoma, 15 cases of Graves
disease, 15 cases of Hashimoto's thyroiditis. RESULTS: The
pathological analysis of resection thyroid showed a high coincidence with
that diagnosed by preoperative fine needle aspiration biopsy (FNAB), with
coincidence rate of 84.48%. The results showed that the expressions of
TGF-β 1 in the thyroid cancers were significantly higher than in
other benign thyroid lesions and normal thyroid tissues (P< 0.05). Moreover,
high expression of TGFβ 1 was found to closely related with the
occurrence of thyroid cancers, while there was no significant difference of
TGFβ 1 expression between different thyroid cancers. CONCLUSION: The overexpression of TGF-β 1 is associated with
the occurrence of thyroid cancer, which can be used as a candidate for the
diagnosis and prognosis of thyroid cancer.
