Affiliations: [a] Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China | [b] Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China | [c] Department of Ophthalmology and optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
Correspondence:
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Corresponding author: Ju Mei, Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China. Tel.: +86 21 25078041; Fax: +86 21 25078041; E-mail:[email protected]
Abstract:
BACKGROUND: Matrix-remodeling associated 5 (MXRA5) has recently
been one of the frequently mutated gene but its role in non-small cell lung
cancer (NSCLC) remains unclear. OBJECTIVE: To identify whether MXRA5 could be applied as a novel
prognostic marker for NSCLC. METHODS AND RESULTS: In this study, we proved that mRNA and protein
expression of MXRA5 in 166 NSCLC patients' tissues by Quantitative Real-Time
PCR and immunohistochemical staining respectively. Moreover, the correlation
between MXRA5 protein expression and clinicopathological features and
prognosis in NSCLC patients was evaluated. Our results revealed that the
over-expression of MXRA5 was significantly correlated with age (P= 0.049),
differentiation (P= 0.003), tumor-node-metastasis (TNM) stage (P= 0.017) and
smoking cigarette (P= 0.007). In addition, it also showed that patients with
higher MXRA5 protein expression had significantly shorter overall survival
(P < 0.001). Multivariate analysis indicated that over-expression of MXRA5
protein was an independent prognostic factor for NSCLC. CONCLUSIONS: MXRA5 protein is aberrantly expressed in NSCLC and the
high MXRA5 expression is correlated with tumor progression and overall
survival. These results indicated the potential value of MXRA5 as a novel
therapeutic target for the treatment of NSCLC.
