TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients

Subtitle:

Article type: Research Article

Authors: Song, Yan | Liu, Dan | He, Guoping^*

Affiliations: School of Nursing, Central South University, Changsha, Hunan, China

Correspondence: [*] Corresponding author: Guoping He, School of Nursing, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China. Tel.: +86 13507318163; E-mail:[email protected]

Abstract: BACKGROUND: The significance of transketolase-like enzyme 1 (TKTL1) and p63 in the clinical progression and prognosis of gastric cancer patients has not been established. OBJECTIVE: This study investigated the expression of TKTL1 and p63 in gastric cancer and their clinical significance. METHODS: TKTL1 and p63 expression in 101 gastric cancer tissue specimens and 25 normal gastric mucosa tissues were detected by immunohistochemistry (IHC). RESULTS: The percentage of positive TKTL1 and p63 expression in gastric carcinomas was significantly higher than that in normal gastric mucosa tissues (P < 0.05). Positive TKTL1 and p63 expression significantly correlated with larger tumor size, deeper invasion, higher TNM stage, and lymph node metastasis (P< 0.05). The expression of TKTL1 significantly correlated with p63 expression in gastric cancer tissues (r = 0.476, P < 0.01). Univariate analysis revealed that positive TKTL1 and/or positive p63 expression correlated significantly with shorter survival and lower 5-year survival rate (P = 0.001). Cox multivariate analysis demonstrated that expression of TKTL1 and p63 is an independent prognostic factor (P < 0.05) in gastric cancer. CONCLUSIONS: Both TKTL1 and p63 are independent prognostic factors of the poor outcome of gastric cancer patients.

Keywords: TKTL1, p63, gastric cancer, prognosis

DOI: 10.3233/CBM-150499

Journal: Cancer Biomarkers, vol. 15, no. 5, pp. 591-597, 2015