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Subtitle:
Article type: Research Article
Authors: Sun, Pengdaa | Sun, Dongb | Wang, Xudonga | Liu, Tianzhoua | Ma, Zhiminga | Duan, Liweic; *
Affiliations: [a] Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China | [b] Ethics Committee, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China | [c] Department of Gastroenterology, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China
Correspondence: [*] Corresponding author: Liwei Duan, Department of Internal Gastroenterology, 2nd Affiliated Hospital of Jilin University, Changchun 130041, Jilin, China. Tel.: +1 86 431 88796978; E-mail: spd52291@163
Abstract: microRNAs (miRNAs) are small non-coding RNAs that play important role in a variety of biological processes, and aberrant expression of miRNA is always associated with tumor progression and invasion. However, the role of miR-206 in colorectal cancer (CRC) is still unclear. In this study, the expression of miR-206 in CRC tissue was compared to paired normal adjacent tissue, and results indicate that miRNA-206 levels are significantly lower in CRC tissue compared to control tissue. Kaplan-Meier analysis showed that patients with low miR-206 expression had significantly poorer overall survival. In addition, we found that over-expression of miR-206 can inhibit CRC cell migration and invasion. In conclusion, our results suggest that miR-206 functions as a tumor suppressor by inhibiting CRC migration and invasion. These findings suggest that miR-206 may be useful as a new potential therapeutic target for CRC.
Keywords: miR-206, colorectal cancer, prognosis, cell growth and invasion
DOI: 10.3233/CBM-150489
Journal: Cancer Biomarkers, vol. 15, no. 4, pp. 391-396, 2015
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