Affiliations: [a] Department of Pathology, Caoxian People’s Hospital of Shandong, Heze, Shandong, China | [b] Department of Pathology, Chengwuxian People’s Hospital of Shandong, Heze, Shandong, China | [c] Department of Pathology, Diseases in Caoxian Hospital of Traditional Chinese Medicine of Shandong, Heze, Shandong, China | [d] Department of Clinical Laboratory, Caoxian Maternal and Child Health and Family Planning Service Center of Shandong, Heze, Shandong, China
Correspondence:
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Corresponding author: Xiaojuan Jia, Department of Pathology, Caoxian People’s Hospital of Shandong, Fumin Road, Heze, Shandong 274400, China. Tel.: +86 530 3490990; E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: BACKGROUND: Gastric cancer is a prevalent malignant around the world. Aberrantly expression of microRNAs (miRNAs) contributes to the progression of tumors. The aim of this study was to investigate the expression and role of miR-892a in gastric cancer. METHODS: A total of 119 gastric cancer patients were enrolled in this study. And the expression of miR-892a in gastric cancer tissues and cells was measured using RT-qPCR analysis. Kaplan-Meier plotter and multivariate Cox regression analysis were used to explore the prognostic value of miR-892a in gastric cancer. The biological function of miR-892a in gastric cancer cells was evaluated using CCK-8 assays and Transwell assays. RESULTS: The expression of miR-892a was high-expressed in gastric cancer tissues and cells. The miR-892a expression was associated with tumor size, differentiation, lymph node metastasis, and TNM stages. Gastric cancer patients with high miR-892a expression showed a short overall survival rate. Overexpression of miR-892a promoted cell proliferation, migration, and invasion of gastric cancer cells. CONCLUSION: miR-892a was upregulated and predictor of poor prognosis in gastric cancer patients. The miR-892a in gastric cancer cells significantly promoted cell proliferative, migratory, and invasive properties. Furthermore, miR-892a may be served as a prognostic marker as well as a therapeutic target for gastric cancer.
