Reduced mean platelet volume is associated with poor prognosis in esophageal cancer

Article type: Research Article

Authors: Shen, Wenjie^{a; *} | Cui, Ming-Ming^b | Wang, Xin^b | Wang, Rui-Tao^{b; c; *}

Affiliations: [a] Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China | [b] Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, Heilongjiang, China | [c] Heilongjiang Academy of Medical Science, Harbin 150081, Heilongjiang, China

Correspondence: [*] Corresponding authors: Wenjie Shen, Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, NO. 51 Fucheng road, Haidian district, Beijing 100048, China. Tel.: +86 010 66867076; Fax: +86 010 66867071; E-mail: [email protected],DepartmentofInternalMedicine,HarbinMedicalUniversityCancerHospital,HarbinMedicalUniversity,NO.150HapingST,NangangDistrict,Harbin150081,Heilongjiang,China.Tel.:+8645186298352;Fax:+8645186298353;E-mail:[email protected].

Abstract: BACKGROUND: Esophageal cancer (EC) is the sixth most common cause of death from cancer. Altered mean platelet volume (MPV) levels were found in patients with malignancies. OBJECTIVE: The present study investigated whether MPV can predict the survival in EC patients. MEHTODS: The clinical data of 236 consecutive EC patients between January 2009 and December 2009 in our center were retrospectively analyzed. The overall survival rate was estimated using Kaplan-Meier method. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis. RESULTS: Decreased MPV was significantly correlated with tumor location and tumor differentiation (p< 0.001). Moreover, survival analysis revealed that the overall survival of patients with MPV ⩽ 7.4 fL was significantly shorter than that of those with MPV > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic factor for overall survival. CONCLUSIONS: Reduced MPV is associated with worse survival outcome in EC.

Keywords: Esophageal cancer, mean platelet volume, prognosis

DOI: 10.3233/CBM-181231

Journal: Cancer Biomarkers, vol. 22, no. 3, pp. 559-563, 2018