Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study

Article type: Research Article

Authors: Zuo, Li^{a; 1} | Ying, Jiang-Shan^{a; 1} | Zhang, Feng-Chun^{b; *} | Xu, Ying-Chun^{c; *}

Affiliations: [a] Department of Oncology, Fudan University Shanghai Cancer Center, Minhang Branch, Shanghai, China | [b] Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University, Suzhou, Jiangsu, China | [c] Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China

Correspondence: [*] Corresponding authors: Feng-Chun Zhang, Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University, 118 Wansheng Street, Suzhou 215021, Jiangsu, China. Tel.: +86 512 62629131; Fax: +86 512 62629658; E-mail: [email protected];Ying-ChunXu,DepartmentofOncology,RenjiHospital,ShanghaiJiaoTongUniversity,Shanghai200127,China.E-mail:[email protected].

Note: [1] Li Zuo and Jiang-Shan Ying contributed equally to the study.

Abstract: OBJECTIVE: To evaluate the correlation of katanin P60 expression with clinicopathological grade and overall survival (OS) in patients with breast cancer (BC). METHODS: Three hundred and four operative BC patients were retrospectively reviewed in this cohort study. Tumor tissue sample was acquired from each patient during surgery. Immunofluorescent staining was used to assess katanin P60 expression. RESULTS: There were 265 BC patients with katanin P60 negative expression and 75 patients with katanin P60 positive expression. Higher N stage (p< 0.001) and TNM stage (p< 0.001) were observed in katanin P60 positive expression group compared to katanin P60 negative expression group. Kaplan-Meier (K-M) curves showed association of katanin P60 positive expression status with shorter OS. Multivariate Cox analysis illustrated katanin P60 positive expression (p< 0.001) could independently predict worse OS. Subgroups analysis indicated that katanin P60 positive expression correlated with worse OS in patients of TNM stage II (p= 0.001) and stage III (p=0.001), while no correlation was found between katanin P60 expression and OS in BC patients with stage I (p= 0.538). According to molecular subtypes, katanin P60 positive expression was correlated with shorter OS in patients with HER2+HR+ (p< 0.001), HER2+HR- (p< 0.001) and HER2-HR- (p= 0.001) status compared to katanin P60 negative expression, while no correlation between katanin P60 expression and OS was observed in patients with HER2-HR+ (p= 0.073). CONCLUSION: Katanin P60 positive expression was correlated with higher lymph node metastasis and worse OS, and it could be regarded as a novel and convincing biomarker to independently predict the prognosis of BC patients.

Keywords: Tumor tissue, katanin P60, breast cancer, prognosis

DOI: 10.3233/CBM-170666

Journal: Cancer Biomarkers, vol. 21, no. 2, pp. 425-432, 2018