Affiliations: [a] Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China | [b] Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, China
Correspondence:
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Corresponding author: Jian Suo, Chunxi Wang, The First Hospital of Jilin University, NO. 71 Xinmin Street, Changchun, Jilin 130021, China. Tel.: +86 0431 88781505; E-mail: [email protected];[email protected].
Abstract: BACKGROUND: An overwhelming amount of evidence has emerged suggesting that dysregulated microRNAs (miRNAs) play crucial roles in tumorigenesis. OBJECTIVE: The study was to analyze tissue/serum miR-144 expression in gastric cancer and then evaluate their potential to predict the prognosis of gastric cancer. METHODS: We examined miR-144 levels in tissues and peripheral blood samples from 96 gastric cancer patients using real-time PCR. Then the association between tissue/serum miR-144 levels and clinicopathological parameters was determined. RESULTS: The expression levels of miR-144 were significantly down-regulated in the cancerous tissue and serum samples from gastric cancer patients. Serum miR-144 was able to differentiate the gastric cancer patients from healthy controls with high accuracy. In addition, tissue and serum miR-144 levels were both associated with clinical stage and lymph node metastasis. Moreover, patients with lower tissue or serum miR-144 suffered worse 5 year overall survival and disease free survival. CONCLUSIONS: Taken together, our data support the potential clinical value of tissue and serum miR-144 as prognostic biomarkers in gastric cancer.
Keywords: Biomarker, miR-144, prognosis, gastric cancer
