Pseudoangiomatous stromal hyperplasia of the breast, imaging and clinical perspective: A review

Article type: Review Article

Authors: Alikhassi, Afsaneh^a; | Skarpathiotakis, Mia^a | Lu, Fang-l^b | Curpen, Belinda^a

Affiliations: [a] Division of Breast Imaging, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada | [b] Precision Diagnostics and Therapeutics Program (Laboratory Medicine), Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

Correspondence: [*] Corresponding author: Afsaneh Alikhassi, Assistant Professor, Division of Breast Imaging, Staff Radiologist, Department of Medical Imaging, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M6, Toronto, ON, M4N 3M5, Canada. E-mail: [email protected]

Abstract: Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast pathology, which most commonly presents incidentally along with other breast pathologies. The etiology and pathogenesis of PASH are still unknown; however, there is some evidence suggesting PASH is hormone dependent. The clinical history, presentation, and imaging appearance of PASH are variable. Clinically, PASH has a wide spectrum of presentations, from being silent to gigantomastia. On imaging, PASH demonstrates various benign to suspicious features. Here we summarize PASH’s clinical presentation, histopathology, imaging features, and management.

Keywords: Breast ultrasound, breast MRI, mammography, PASH

DOI: 10.3233/BD-220072

Journal: Breast Disease, vol. 42, no. 1, pp. 147-153, 2023