Affiliations: [a] Department of Surgical Oncology, Sri Shankara Cancer Hospital and Research Centre, Basavangudi, Bangalore, Karnataka, India | [b] Department of Breast Radiology, Sri Shankara Cancer Hospital and Research Centre, Basavangudi, Bangalore, Karnataka, India | [c] Department of Pathology, Sri Shankara Cancer Hospital and Research Centre, Basavangudi, Bangalore, Karnataka, India | [d] PESIMSR, Andhra Pradesh, India
Correspondence:
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Corresponding author: Kanyadhara Lohita Krishna, Department of Surgical Oncology, Sri Shankara Cancer Hospital and Research Centre, 1st Cross Shankarapuram, Basavangudi, Bangalore, Karnataka, 560004, India. Tel.: +91 9008661451; E-mail: [email protected]
Abstract: BACKGROUND AND AIM:Traditionally lumpectomy as a part of breast-conserving surgery (BCS) is performed by palpation-guided method leading to positive margins and large excision volumes. There is no evidence suggesting that wide margin excisions decrease intra-breast tumour recurrence. Various perioperative techniques are used for margin assessment. We aimed to compare three commonly used techniques, i.e., ultrasound-guided surgery, palpation-guided surgery and cavity shaving for attaining negative margins and estimating the extent of healthy breast tissue resection. METHOD:A prospective comparative study was performed on 90 patients who underwent breast conservation surgery for early breast cancer between August 2018 and June 2019. Tumour excision with a minimum of 1 cm margin was done either using ultrasound, palpation or cavity shaving. Histopathological evaluation was done to assess the margin status and excess amount of resected normal breast tissue. Calculated resection ratio (CRR) defining the excess amount of the resected breast tissue was achieved by dividing the total resection volume (TRV) by optimal resection volume (ORV). The time taken for excision was also recorded. RESULTS:Histopathology of all 90 patients (30 in each group) revealed a negative resection margin in 93.3% of 30 patients in palpation-guided surgery group and 100% in both ultrasound-guided surgery and cavity shaving groups. Two patients (6.7%) from the cavity shaving group had positive margins on initial lumpectomy but shave margins were negative. TRV was significantly less in the ultrasound-guided surgery group compared to the palpation-guided surgery group and cavity shaving group (76.9 cm3, 94.7 cm3 and 126.3 cm3 respectively; p < 0.0051). CRR was 1.2 in ultrasound group compared to 1.9 in palpation group and 2.1 in cavity shave group which was also statistically significant (p < 0.0001).Excision time was significantly less (p < 0.001) in palpation-guided surgery group (13.8 min) compared to cavity shaving group (15.1 min) and ultrasound-guided group (19.4 min). CONCLUSION:Ultrasound-guided surgery is more accurate in attaining negative margins with the removal of least amount of healthy breast tissue compared to palpation-guided surgery and cavity shaving.
Keywords: Breast-conserving surgery, intraoperative ultrasound, cavity shaving technique, palpation-guided lumpectomy, normal breast tissue preservation
DOI: 10.3233/BD-200443
Journal: Breast Disease, vol. 39, no. 3-4, pp. 127-135, 2020
