Affiliations: Photonics and Nanotechnology Section, Bhabha Atomic Research Centre Facility, Visakhapatnam, India | Atomic and Molecular Physics Division, Bhabha Atomic Research Centre, Mumbai, India | Chilakapati Laboratory, Advanced Centre for Treatment Research and Education in Cancer, Navi Mumbai, India
Note:  Corresponding author: K. Divakar Rao, Photonics and Nanotechnology Section, Bhabha Atomic Research Centre Facility, Visakhapatnam 530 012, India. Tel./Fax: +91 891 2892122; E-mail: [email protected]
Abstract: Biomedical optical imaging and optical spectroscopy are rapidly emerging as strong contenders for non-invasive optical biopsy. In biomedical imaging, Optical Coherence Tomography (OCT) is an established imaging modality for non-contact depth-resolved three-dimensional imaging with micrometer scale resolution. OCT provides label-free micro-structural morphological information of the tissue. Raman spectroscopy is a complementary tool for obtaining molecular-specific information for diagnosis. This article provides a brief overview of the underlying principles of OCT and Raman spectroscopy, their instrumentation with representative latest developments in cancer diagnosis.
Keywords: Optical coherence tomography, Raman spectroscopy, cancer diagnosis