Affiliations: Joint Graduate Program in Biomedical Engineering,The University of Memphis and The University of Tennessee Health Science Center, Memphis, TN, USA | Adjunct Faculty of Graduate School of Science and Engineering, Işık University, Maslak, Istanbul, Turkey
Note: [] Correspondence: Semahat S Demir, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152-3210, USA; tel + 1 901 678 3170; fax +1 901 678 5281; email [email protected]
Abstract: Five decades of histological, electrophysiological, pharmacological and biochemical investigations exist, but relatively little is known regarding the ionic mechanisms underlying the action potential variations in the ventricle associated with healthy and disease conditions. The computational modelling in murine ventricular myocytes can complement our knowledge of the experimental data and provide us with more quantitative descriptions in understanding different conditions related to normal and disease conditions. This paper initially reviews the theoretical modelling for cardiac ventricular action potentials of various species and the related experimental work. It then focuses on the progress of computational modelling of cardiac ventricular cells for normal, diabetic and spontaneously hypertensive rats. Also presented is the recent modelling efforts of the action potential in mouse ventricular cells. The computational insights gained into the ionic mechanisms in rodents will enhance our understanding of the heart and provide us with new knowledge for future studies to treat cardiac diseases in children and adults.
Keywords: mathematical modelling, ventricular myocytes, cell membrane, simulations, model development
