Affiliations: Department of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada | Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada | Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia
Note: [] Correspondence to: Kalman Kovacs, Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada. Tel.: +1 416 864 5851; ext: 2365; Fax: +1 416 864 5648; E-mail: [email protected]
Abstract: Ghrelin is a hormone that stimulates growth hormone (GH) release, and regulates appetite and feeding habits. It is synthesized and expressed to varying degrees in several organs and neoplasms. Its presence has been reported in the gastrointestinal and respiratory tracts, endocrine organs, cardiovascular system, kidney and central nervous system. Ghrelin producing cells can be demonstrated in the stomach, intestines, pancreas, kidneys, brain, and pituitary. The present review summarizes findings regarding the function and regulation of ghrelin in different organs and in various diseases.
