After a long period of specialization in science it has been gradually realized that the time has come for coordination, integration and interpretation in Biological Sciences. Advances in Neuroimmune Biology (ANIB) will fulfill, in part, this objective. ANIB deals with the immune-neuroendocrine circuitry as it integrates, coordinates and regulates all biological events in animals and men. This constitutes the Neuroimmune Super system (NISS), the ultimate central regulator of biological processes in animals. Homeostasis is discussed with respect to immune function. The role of the autonomic nervous system, immunological memory, Pavlovian conditioning of immunity, immune deficiency, stress, mast cells and neuroinflammation are included. Therapeutical application of the new knowledge is also considered.