Clinical Hemorheology and Microcirculation - Volume 3, issue 5
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Nine non-diabetic patients with peripheral arterial disease were investigated as for (i) their red cell deformability, using a filterability measurement technique and (ii) the in vitro phosphorylation of their red cell membrane proteins, with special reference to cytoskeletal proteins. The deformability appeared significantly (p < 0.01) reduced in the patients. However, the phosphorylation of erythrocyte membrane proteins was strictly normal. Therefore, the molecular basis for decreased deformability must not reside in some acquired alteration of the cytoskeleton, in vitro phosphorylation being a sensitive probe of cytoskeletal protein organization.
Keywords: Erythrocyte deformability, Membrane protein phosphorylation, Peripheral arterial disease
Abstract: Twenty one ambulatory patients with essential hypertension (10 men, 11 women), 50.6±6.3 years old, had blood pressures of 167.5±17.1 mmHg for systolic and l06.2±9.9 mmHg for diastolic. Most of them were under treatment and target organ involvement was not important. Several parameters were calculated from a sample of venous blood: haemoglobin, haematocrit, P50 standard, carboxyhaemoglobin, red cell 2,3-diphosphoglycerate and erythrocyte filterability rate. As significant different from a group of control, it has been found a higher P50 standard (hypertensives 29.07±1.82 mmHg. vs. controls 27.74±0.86 mmHg, p < 0.05) and a lower filterablity rate (11.41±1.31 μ l.sec−l for hypertensives 15.80±0.83…μ l.sec−l for controls, p < 0.001). The results suggest an augmentation of the rigidity of red blood cells that may have consequences on microcircultion and delivery of oxygen to tissues. The increase in P50 standard eventually connected with the increase in 2,3-DPG (hypertensives 18.56±3.32 μ moles/gHb; controls 12.01±1.32 μ moles/gHb, p < 0.001), could be a way of compensation.
Keywords: erythrocyte filterability, red cell 2,3-diphosphoglycerate, P50 standard, human arterial hypertension
Abstract: Initial-flow-rate (Hémorhéomètre) and positive-pressure filtration systems were used to study the effects of EDTA and heparin on erythrocyte filterability after storage of whole blood for up to 6 hours from venepuncture. Heparin had a time-dependent, adverse effect on filtration through 5 µm diameter pores, causing an increase in platelet microaggregate formation and a decrease in leucocyte filterability. Erythrocyte suspensions from which all contaminating platelets and leucocytes had been removed by prefiltration through Imugard IG500 cotton wool, however, showed no significant alteration in erythrocyte filterability during storage of blood in EDTA or heparin; the filtration values were similar to those of…defibrinated blood. Thus, for both initial-flow-rate and positive-pressure studies of erythrocyte filterability, blood may be stored at room temperature in either dipotassium EDTA (1.5 mg/ml blood) or lithium heparin (15 IU/ml blood) for up to 6 hours after venepuncture.
Abstract: Haematological, biochemical and haemorheological measurements were carried out over 79 days in adjuvant arthritic rats to elucidate the function of the red blood cells in microvascular perfusion of arthritic rats. A slight decrease in the red blood cell count and significant changes in plasma proteins could be measured during the early development of the disease (21st day), and returned nearly to normal values after the syndrome became established. Significant increases in plasma and apparent blood viscosity at low and high shear rates were obtained. Haemorheological changes could be further proved by significant decrease in red cell filtrability, and increase…in the mean extent of red blood cell aggregation.
Abstract: Forty patients with arteriosclerosis obliterans and thirty controls were investigated for erythrocyte deformability with three methods. These methods were Reid and Dormandy’s on whole blood and on washed erythrocytes and the haemorheometer technique. In addition the erythrocyte sedimentation rate, the white blood cell count and the acute phase reactant proteins were measured. Erythrocyte filterability was impaired in patients with the three methods. Signs of both subacute and chronic inflammation are observed in these patients. However there are weak correlations between these signs and the erythrocyte filterability on whole blood, as shown by the stepwise multiple regression analysis (r = 0.337).…In contrast the correlation was closer in controls (r = 0.760). Thus, it is concluded that erythrocyte filterability is impaired in arteriosclerosis obliterans patients at least in part independantly of other blood component alterations.