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A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer's Disease

Article type: Research Article

Authors: Hartmann, Tobiasa | van Wijk, Nickb | Wurtman, Richard J.c | Olde Rikkert, Marcel G.M.d | Sijben, John W.C.b | Soininen, Hilkkae | Vellas, Brunof | Scheltens, Philipg; *

Affiliations: [a] Department of Neurodegeneration and Neurobiology, Deutsches Institut für Demenzprävention, Saarland University, Homburg, Germany | [b] Nutricia Research, Utrecht, The Netherlands | [c] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA | [d] Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The Netherlands | [e] Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland | [f] Department of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, France | [g] Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands

Correspondence: [*] Correspondence to: Philip Scheltens, MD, Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Tel.: +31 20 4440816; Fax: +31 20 4440715; E-mail: [email protected].

Keywords: Alzheimer's disease, membranes, nutritional intervention, phosphatidylcholine, plasma phospholipids, prognostic biomarkers, synaptic dysfunction

DOI: 10.3233/JAD-141137

Journal: Journal of Alzheimer's Disease, vol. 41, no. 3, pp. 715-717, 2014

Accepted 27 May 2014
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Published: 16 July 2014
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Abstract

Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2–3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naïve patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.

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