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Pediatric focally pigmented choroidal melanoma: Imaging with pathological correlation

Article type: Other

Authors: Galluzzi, Paolo | Occhini, Rossella | Cerase, Alfonso; | Toti, Paolo | Hadjistilianou, Theodora | Venturi, Carlo | De Francesco, Sonia

Affiliations: Unit of Neuroimaging and Neurointervention (NINT), Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy | Section of Pathology, Department of Human Pathology and Oncology, University of Siena, Siena, Italy | Unit of Ophthalmology, and Retinoblastoma Referral Center, Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy

Note: [] Corresponding author: Alfonso Cerase, Unit of Neuroimaging and Neurointervention - NINT, Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Policlinico “Santa Maria alle Scotte”, Viale Mario Bracci, 16 53100 Siena, Italy. Tel.: +39 0577 585040/4; Fax: +39 0577 586197; E-mail: [email protected].

Keywords: Choroidal malignant melanoma, computed tomography, focal pigmentation, magnetic resonance imaging, pediatric ocular malignancy

DOI: 10.3233/PNR-13078

Journal: Journal of Pediatric Neuroradiology, vol. 2, no. 4, pp. 333-337, 2013

Received 16 June 2011
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Revision received 8 November 2011
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Accepted 23 January 2012
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Published: 2013
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Abstract

We report a 9-year-old-boy with no predisposing factors who presented with left eye leukocoria from a complete retinal detachment at ophthalmoscopy. Imaging showed an intraocular dome-shaped mass of low to moderate internal reflectivity at ultrasound, low T2-weighted signal intensity, lack of T1-weighted high signal intensity, and subtle gadolinium-enhancement at magnetic resonance imaging, and lack of calcifications at computed tomography. Due to the rapid extensive intraocular growth, the affected eye was enucleated. Pathologic examination showed a choroidal melanoma with only focal pigmentation. Despite its very rare incidence in the pediatric population, choroidal melanoma should be included in the differential diagnosis of leukocoria.