PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

Article type: Short Communication

Authors: Chen, Fan^a | Zhang, Yan^b | Wang, Longcai^c | Wang, Tao^{d; e} | Han, Zhifa^{f; g; h} | Zhang, Haihuaⁱ | Gao, Shanⁱ | Hu, Yang^{i; j; *} | Liu, Guiyou^{a; i; k; *}

Affiliations: [a] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China | [b] Department of Pathology, The Affiliated Hospital of Weifang Medical University, Weifang, China | [c] Department of Anesthesiology, The Affiliated Hospital of Weifang Medical University, Weifang, China | [d] Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China | [e] Chinese Institute for Brain Research, Beijing, China | [f] School of Medicine, School of Pharmaceutical Sciences, THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China | [g] State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China | [h] Department of Pathophysiology, Peking Union Medical College, Beijing, China | [i] Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China | [j] School of Life Science and Technology, Harbin Institute of Technology, Harbin, China | [k] National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China

Correspondence: [*] Correspondence to: Guiyou Liu, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. E-mail: [email protected]. Yang Hu, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China. E-mail: [email protected].

Abstract: We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

Keywords: Alzheimer’s disease, genome-wide association study, multiple sclerosis, PLCG2, rs72824905 variant

DOI: 10.3233/JAD-201140

Journal: Journal of Alzheimer's Disease, vol. 80, no. 1, pp. 71-77, 2021