Lessons from Epidemiologic Research about Risk Factors, Modifiers, and Progression of Late Onset Alzheimer's Disease in New York City at Columbia University Medical Center

Issue title: Alzheimer's Disease: Advances for a New Century

Guest editors: George Perry, Xiongwei Zhu, Mark A. Smith, Aaron Sorensen and Jesús Avila

Article type: Review Article

Authors: Devanand, Devangere^{a; b} | Lee, Joseph^{c; d; e} | Luchsinger, Jose^{e; f; *} | Manly, Jennifer^{c; d; g} | Marder, Karen^{d; g} | Mayeux, Richard^{a; c; d; e; g} | Scarmeas, Nikolaos^{c; d; g} | Schupf, Nicole^{c; d; e} | Stern, Yaakov^{c; d; g}

Affiliations: [a] Department of Psychiatry, Columbia University Medical Center, New York, NY, USA | [b] Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, NY, USA | [c] Gertrude H. Sergievsky Center, New York, NY, USA | [d] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY, USA | [e] Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA | [f] Department of Medicine, Columbia University Medical Center, New York, NY, USA | [g] Department of Neurology, Columbia University Medical Center, New York, NY, USA

Correspondence: [*] Correspondence to: Jose A. Luchsinger, MD, MPH, Columbia University Medical Center, PH9 Center, room 210, 630 West 168th Street, New York, NY 10032, USA. Tel.: +1 212 3054730; E-mail: [email protected].

Abstract: This review summarizes the findings and importance of 12 articles from research at Columbia University in New York City that were among the most cited in the literature between 2006 and 2011. The 12 articles summarized in this review made important contributions to the field of Alzheimer's disease in the last 5 years. Four of the articles established the Mediterranean diet as a food consumption pattern that may prevent Alzheimer's disease in addition to physical activity. Two of the articles advanced our knowledge of predictors of conversion from mild cognitive impairment to dementia. Four of the articles provided important knowledge of risk factors for the progression of Alzheimer's disease and its complications. Lastly, one of the articles laid the theoretical framework for the study of cognitive reserve, an important modifier of the manifestation of Alzheimer's disease. These studies have advanced our knowledge about risk factors, modifiers, and progression of late onset Alzheimer's disease.

Keywords: Alzheimer's disease, conversion, diet, cognitive reserve, epidemiology, genes, mild cognitive impairment, predictors, progression, risk factors

DOI: 10.3233/JAD-2012-129041

Journal: Journal of Alzheimer's Disease, vol. 33, no. s1, pp. S447-S455, 2013