Diffusion Tensor Imaging Surpasses Cerebrospinal Fluid as Predictor of Cognitive Decline and Medial Temporal Lobe Atrophy in Subjective Cognitive Impairment and Mild Cognitive Impairment

Article type: Research Article

Authors: Selnes, Per^{a; b; *} | Aarsland, Dag^{c; d} | Bjørnerud, Atle^{e; f} | Gjerstad, Leif^g | Wallin, Anders^h | Hessen, Erik^a | Reinvang, Ivarⁱ | Grambaite, Ramune^b | Auning, Eirik^j | Kjærvik, Veslemøy Krohn^b | Due-Tønnessen, Paulina^k | Stenset, Vidar^{a; b; 1} | Fladby, Tormod^{a; b}

Affiliations: [a] Department of Neurology, Faculty Division, Akershus University Hospital, University of Oslo, Lørenskog, Norway | [b] Department of Neurology, Akershus University Hospital, Lørenskog, Norway | [c] Psychiatry Clinic, Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway | [d] Department of Neurobiology, Karolinska Institute (KI), Care Sciences and Society, KI-Alzheimer Disease Research Center, Novum, Stockholm | [e] The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway | [f] Department of Physics, University of Oslo, Oslo, Norway | [g] Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway | [h] Institute of Neuroscience and Physiology, University of Gothenburg and Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden | [i] Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway | [j] Department of Geriatric Psychiatry, Akershus University Hospital, Lørenskog, Norway | [k] Department of Radiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

Correspondence: [*] Correspondence to: Per Selnes, Department of Neurology, Akershus University Hospital, 1478 Lørenskog, Norway. Tel.: +47 02900; E-mail: [email protected].

Note: [1] Present address: Department of Neurosurgery, Oslo University Hospital, Ullevaal, Oslo, Norway.

Keywords: Alzheimer's disease, biomarker, cerebrospinal fluid, diffusion tensor imaging, longitudinal study, magnetic resonance brain imaging, mild cognitive impairment, preclinical Alzheimer's disease, subjective cognitive impairment

DOI: 10.3233/JAD-2012-121603

Journal: Journal of Alzheimer's Disease, vol. 33, no. 3, pp. 723-736, 2013