Affiliations: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
Correspondence:
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Correspondence to: Dr. Y.K. Gupta, Professor and Head, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India. Tel.: +91 11 26593282; Fax: +91 11 26588641; 26588663; E-mail: [email protected].
Abstract: The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8–10 weeks.
Keywords: Alzheimer's disease, cognitive impairment, elevated plus maze, Morris water maze, passive avoidance, streptozotocin
