Pathogen Free Conditions Slow the Onset of Neurodegeneration in a Mouse Model of Nerve Growth Factor Deprivation

Article type: Short Communication

Authors: Capsoni, Simona^{a; *} | Carucci, Nicola Maria^a | Cattaneo, Antonino^{a; b}

Affiliations: [a] Laboratory of Neurobiology, Scuola Normale Superiore, Pisa, Italy | [b] European Brain Research Institute, Rome, Italy

Correspondence: [*] Correspondence to: Prof. Simona Capsoni, Laboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy. Tel.: +39 0503153198, Fax: +39 0503153220; E-mail: [email protected].

Abstract: Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbial environment and the onset of neurodegeneration in Alzheimer's disease animal models are lacking. Here we show that the onset of neurodegeneration that transgenic mice develop when raised in conventional husbandry slows down when raising anti-nerve growth factor transgenic mice in a murine pathogen free condition.

Keywords: Amyloid-β, deprivation, interleukin-6, microglia, murine pathogen free, nerve growth factor, phosphorylated tau, systemic inflammation

DOI: 10.3233/JAD-2012-120427

Journal: Journal of Alzheimer's Disease, vol. 31, no. 1, pp. 1-6, 2012