Passive (Amyloid-β) Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice

Article type: Research Article

Authors: Liu, Ying^a | Lee, Michael K.^{a; b; *} | James, Maria M.^a | Price, Donald L.^{a; c} | Borchelt, David R.^a | Troncoso, Juan C.^{a; c} | Oh, Esther S.^{a; d; e; *}

Affiliations: [a] Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA | [b] Department of Neuroscience and Institute for Translational Neuroscience, University of Minnesota-Twin Cities, Minneapolis, MN, USA | [c] Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA | [d] Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA | [e] Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence: [*] Correspondence to: Esther S. Oh, MD, 558 Ross Research Building, 720 Rutland Ave., Baltimore, MD 21205, USA. Tel.: +1 410 955 5632; Fax: +1 410 955 9777; E-mail: [email protected]. Michael K. Lee, PhD, Department of Neuroscience and Institute for Translational Neuroscience, University of Minnesota-Twin Cities, 2102 6th S.E. Minneapolis, MN 55455, USA. Tel.: +1 612 626 8472; Fax: +1 612 626 2032; Email: [email protected].

Note: [1] D.R. Borchelt's present address: University of Florida, Gainesville Florida, USA.

Keywords: Amyloid-β, axon, immunotherapy, neurodegeneration, serotonergic

DOI: 10.3233/JAD-2010-101602

Journal: Journal of Alzheimer's Disease, vol. 23, no. 2, pp. 271-279, 2011