Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies

Article type: Review Article

Authors: Simonsen, Anders Lykkemark^* | Danborg, Pia Brandt | Gøtzsche, Peter Christian

Affiliations: Nordic Cochrane Centre, Copenhagen, Denmark

Correspondence: [*] Address for correspondence: A.L. Simonsen, Nordic Cochrane Centre, Rigshospitalet, 7811, Blegdamsvej 9, 2100 København Ø, Denmark. Tel.: +45 42941965; E-mail: [email protected].

Abstract: BACKGROUND:Sexual dysfunction is a common adverse effect of selective serotonin reuptake inhibitors (SSRIs) and there is a concern that the sexual harms might persist after discontinuation of therapy. OBJECTIVE:To assess whether the use of SSRIs in animals can lead to persistent sexual dysfunction. METHODS:Systematic review of animal studies measuring sexual behaviour after end of treatment with SSRIs or serotonin norepinephrine reuptake inhibitors. DATA SOURCES:We searched PubMed and EMBASE. RESULTS:We included 14 studies. The general quality of the studies was poor. Only four studies reported use of randomisation and none mentioned allocation concealment. All studies used placebo and were therefore blinded. For rats exposed to SSRIs compared with those exposed to placebo, we found a higher risk of no mounting behaviour (RR = 0.73; 95% CI = 0.62–0.86), no intromission behaviour (RR = 0.74; 95% CI = 0.60–0.92) and no ejaculation behaviour (RR = 0.49, 95% CI = 0.24–1.00). CONCLUSION:Our results showed substantial and lasting effects on sexual behaviour in rats after exposure to an SSRI early in life on important sexual outcomes.

Keywords: Selective serotonin reuptake inhibitors (SSRIs), long lasting harm, permanent sexual dysfunction, animal studies, systematic review

DOI: 10.3233/JRS-160668

Journal: International Journal of Risk & Safety in Medicine, vol. 28, no. 1, pp. 1-12, 2016