Computational Modeling of Bienzyme Biosensor with Different Initial and Boundary Conditions

Article type: Research Article

Authors: Ašeris, Vytautas^; | Baronas, Romas | Kulys, Juozas

Affiliations: Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania, e-mail: [email protected], [email protected] | Institute of Biochemistry, Vilnius University, Mokslininkų 12, LT-08662 Vilnius, Lithuania, e-mail: [email protected]

Note: [] Corresponding author

Abstract: Two mathematical models of an amperometric bienzyme biosensor are analysed digitally. The models hold different boundary conditions describing the singularity of the electrode (transducer). The influence of the initial and boundary conditions on the biosensors action at different sets of parameters is analysed. The digital simulation at the transient and steady-state conditions was carried out by using finite difference technique. The comparison of the simulation results revealed that some of the calculated parameters, i.e. response and sensitivity is the same, while the others, i.e. half-time of the steady-state is significantly different for distinct models.

Keywords: modelling, biosensor, catalase, peroxidase, diffusion

Journal: Informatica, vol. 24, no. 4, pp. 505-521, 2013