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A viscoelastic model of shear-induced hemolysis in laminar flow

Article type: Research Article

Authors: Arwatz, G.; | Smits, A.J.

Affiliations: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, USA

Note: [] Address for correspondence: Gilad Arwatz, Mechanical and Aerospace Engineering, Engineering Quad Room D214, Princeton, NJ 08544, USA. Fax: +1 609 258 6109; E-mail: [email protected]

Keywords: Hemolysis, Kelvin–Voigt, Couette flow, blood experiment, erythrocyte

DOI: 10.3233/BIR-130626

Journal: Biorheology, vol. 50, no. 1-2, pp. 45-55, 2013

Received 25 September 2012
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Accepted 18 February 2013
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Published: 2013
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Abstract

We present measurements of human blood hemolysis caused by laminar shear stresses ranging from 50 to 500 Pa for exposure times extending from 60 to 300 s using a Taylor–Couette device. A viscoelastic model is proposed that captures the response of the red blood cells to shear stress. The model is based on well-established mechanical properties of the red blood cell membrane, and shows good agreement with data from the experiments presented here, as well as data from the existing literature. Two characteristic time scales are identified: a fast time scale corresponding to the relaxation time of the red blood cell membrane and a slow time scale that represents the onset of plasticity and is related to hemoglobin release from a damaged cell. The model proposed here collapses the available data over almost five orders of magnitude in exposure time and shear stresses up to 500 Pa.

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